Ovarian Rejuvenation Therapy (PRP)
A trailblazing program for those seeking to produce new eggs.
Ovarian rejuvenation therapy seeks to help women produce new eggs to improve their chances of conception. This technique may help women facing early menopause, low egg count or age-related fertility challenges to have their own biological child.
Demeter Fertility leads the way
In 2017, Dr David Knight became the first doctor in Australia to perform PRP ovarian rejuvenation, pioneering a procedure that has since brought hope to women across Australia and internationally. Since then, he has performed hundreds of ovarian rejuvenation procedures, consistently refining the technique in line with evolving research and clinical insights to enhance outcomes.
Today, the Demeter Fertility Ovarian Rejuvenation Program represents a truly holistic approach to addressing ovarian ageing. It integrates advanced PRP therapy for ovarian rejuvenation with tailored fertility care and patient support.
To our knowledge, it remains the only dedicated ovarian rejuvenation program of its kind worldwide – a testament to Dr Knight’s leadership in reproductive medicine.
Dr Knight’s commitment to innovation in reproductive medicine continues to provide new hope for women who have previously been told their options were limited.
What is Ovarian Rejuvenation Therapy?
Ovarian rejuvenation therapy is an innovative treatment designed to support ovarian function in women who face fertility challenges such as low ovarian reserve, premature ovarian failure or age-related decline in fertility.
Using PRP (platelet-rich plasma) technology, this therapy may help stimulate the development of follicles and improve the hormonal environment within the ovaries.
At Demeter Fertility, we are proud to be the first clinic in Australia to offer this treatment, with Dr David Knight performing the first intraovarian PRP procedure in the country in 2017.
Helping women produce new eggs
The traditional view, supported by decades of research, is that women are born with all the eggs they will ever have. Egg count decreases with age leading to a decline in fertility until women are no longer able to conceive.
But medical research advances. The research into ovarian rejuvenation contends the traditional view. It suggests that, when done correctly, the right number of times followed by as many cycles as possible – ovarian rejuvenation therapy may be able to ‘restart’ the ovaries.
To put it another way, women’s bodies may be able to produce new eggs, giving them a second chance at having a baby of their own.
How does PRP for Ovarian Rejuvenation work?
Ovarian rejuvenation is a surgical procedure in which platelet-rich-plasma (PRP) is collected from the patient and then injected directly into her ovaries under ultrasound guidance.
The exact treatment protocol varies from patient to patient depending on age, fertility diagnosis and patient preferences. A standard treatment program, devised through significant research and development, may look like this.
Platelets are rich in growth factors, which are thought to stimulate dormant cells in the ovarian tissue. This process may enhance follicular development and improve key fertility markers such as anti-Müllerian hormone (AMH) and antral follicle count – particularly relevant for those exploring ovarian rejuvenation for low AMH.
Does Ovarian Rejuvenation work?
A 2024 systematic review found that, “PRP treatment resulted in a statistically significant improvement in the main fertility parameters of diminished ovarian reserve women.” The review includes 38 studies of 2256 women aged 18-55 with diminished ovarian reserve, premature ovarian failure or premature ovarian insufficiency.
Our Ovarian Rejuvenation Program
Demeter Fertility’s ovarian rejuvenation has been developed for women who have been diagnosed with decreased or impaired ovarian function.
Ovarian rejuvenation therapy may be considered for women who:
- Have low or borderline AMH levels
- Have been diagnosed with premature ovarian insufficiency or failure
- Are over the age of 38 and experiencing age-related fertility decline
- Have experienced recurrent implantation failure in previous IVF cycles
- Are seeking an alternative to egg donation
The program includes:
- Comprehensive fertility assessment to determine suitability
- Personalised treatment plans including PRP ovarian injections
- Access to our IVF Over 40s Program, tailored to the needs of mature patients
- Ongoing support and cycle monitoring from our experienced fertility team
This program is built on over a decade of clinical leadership in fertility innovation and backed by Demeter’s values of compassionate care and evidence-informed treatment.
What does Ovarian Rejuvenation cost?
Please contact our team for a personalised quote and information about available payment plans.
We understand that each fertility journey is different. That’s why every patient at Demeter Fertility receives a customised assessment before being accepted into the program.
Ready to explore your options?
Demeter Fertility has led the way in ovarian rejuvenation in Australia. Our founder, Dr David Knight is one of the nation’s most forward-thinking fertility specialists. If you’d welcome our advice about ovarian rejuvenation, please contact us.