Ovarian Rejuvenation

Ovarian Rejuvenation is an experimental procedure that may create new eggs in the ovaries of women who are unable to conceive because of early menopause, low egg counts, advanced maternal age, or women who want to continue to have their ovaries produce eggs so that natural hormones are produced.


Medicine has long thought that new eggs do not develop in the ovaries and, according to the current scientific understanding of ovarian physiology, a woman is born with all the eggs that will be available for conception during her reproductive life. It is a scientifically undisputed fact that a woman’s supply of eggs diminishes both in number and quality as she ages.

Who might it help

Any women who is in good physical health and falls into one or more of the following patient categories 

-        Menopausal women under the age of 50

-        Infertile women of all ages (low egg reserve and low AMH levels) 

-        Women with premature ovarian failure

Potential benefits of ovarian rejuvenation therapy

The benefits of this procedure is the possibility of achieving pregnancy using the patient’s own eggs, which had not been possible or very unlikely prior to the procedure. 

Since late 2015, clinicians in Greece have conducted preclinical trials to rejuvenate the ovaries of menopausal women, restore fertility and pursue pregnancy. Of the over 60 women aged 45-64 who have received the treatment so far:

·         Over 75% now have the option of natural pregnancy or in vitro fertilization.

·         Over 75% have also seen overall hormone levels return to youthful levels,

·         9 have begun successful pregnancies.

·         2 have had live births. 

2018 has been a watershed year for publications in this area. A representative sample of these publications are listed below.

The Drs Knight and Jessup at Demeter Fertility have now been performing the procedure for more than 12 months, and now offer the Demeter Fertility Modified Inovium™ Ovarian Rejuvenation Program. 

“There have been a number of reported pregnancies worldwide following trials of the treatment in Greece, Japan, Spain and the USA and also here in Australia, now that there is at least one live birth reported, we are confident that this treatment has the potential to turn back the clock in women previously unable to conceive. This is an extraordinary result and may well change human reproduction in the same way that the oral contraceptive pill has”, says Dr Knight.

Dr Knight’s webpage has further information about the techniques used for ovarian rejuvenation.

For more information on the Ovarian Rejuvenation Program, please contact us.

Published Clinical Results

There are now publications appearing that support both an increase in egg numbers, and in IVF, an improvement in embryo quality. 

Gynecologic and obstetric investigation
https://www.ncbi.nlm.nih.gov/p... 

Gynecological Endocrinolgy, 2018:

https://doi.org/10.1080/09513590.2018.1445219

Fertility and Sterility, 2018:

 https://doi.org/10.1016/j.fertnstert.2018.04.025

Fertility and Sterility, 2018:

 https://doi.org/10.1016/j.fertnstert.2018.01.004