If you have just been given a low AMH result, the question you are probably asking is whether anything can be done about the number itself. The honest answer is that nothing reliably raises AMH permanently, and no supplement, diet or protocol has been shown to restore ovarian reserve. What can sometimes change is how your ovaries respond to an IVF cycle, and that is where ovarian rejuvenation comes in. Platelet rich plasma prepared from your own blood is injected into the ovaries with the aim of improving follicle development, and a 2024 review of 38 studies found significant improvement in fertility markers for women with diminished ovarian reserve. It is not suitable for everyone, results vary, and better markers are not the same as a pregnancy. This article is for people who already have the diagnosis and want to know what their realistic options are.
First, what your AMH result actually means
AMH tells you about egg quantity. It does not tell you about egg quality, and it is quality that determines whether an embryo is chromosomally normal.
This distinction matters enormously when you are deciding what to do next. A 34 year old with an AMH of 3 pmol/L and a 44 year old with the same result are not in the same clinical position at all, because their egg quality differs even though the number on the page is identical. The younger woman may need very few eggs to find a good one. The older woman may need considerably more.
If you want the full explanation of the test and what the ranges mean, our guide to ovarian reserve and low AMH covers it, and the AMH testing page explains how it is interpreted alongside your antral follicle count and FSH.
Can you improve ovarian reserve naturally?
This is usually the first thing people search after a low result, so it deserves a direct answer.
No supplement, herb, diet or lifestyle change has been shown to permanently increase AMH or restore ovarian reserve. Anything marketed on that promise is overstating the evidence.
What lifestyle can influence is your general reproductive health and possibly your response to treatment. Stopping smoking, correcting a vitamin D deficiency, managing thyroid dysfunction or PCOS, maintaining a healthy weight and reducing alcohol are all worth doing. Our review of fertility supplements sets out what the evidence supports and what it does not.
None of that changes the underlying reserve. It is groundwork, not treatment.
Low AMH and ovarian rejuvenation: what PRP is actually trying to do
Ovarian rejuvenation takes a different approach for low AMH patients. Rather than trying to influence the ovary indirectly through diet or supplements, it delivers concentrated growth factors straight into the ovarian tissue.
Blood is drawn, spun to concentrate the platelets, and the resulting plasma is injected into both ovaries under ultrasound guidance. The theory is that those growth factors improve blood supply to the tissue and encourage dormant follicles to begin developing.
For someone with low AMH, the specific goal is a better response to stimulation. Not a normal ovarian reserve, which is not achievable, but more follicles recruited, more eggs collected and more embryos available from a cycle that previously produced very few. The complete guide to ovarian rejuvenation covers the mechanism and the procedure in full.
Can PRP improve AMH levels?
Studies have reported improvements in AMH and antral follicle count following ovarian PRP. The 2024 systematic review in the Journal of Ovarian Research, covering 38 studies and 2,256 women with diminished ovarian reserve, premature ovarian failure or premature ovarian insufficiency, concluded that PRP produced a statistically significant improvement in the main fertility parameters.
Three qualifications belong alongside that.
Results vary widely between individuals, and some women see no measurable change at all.
An improved AMH is a proxy, not an outcome. It suggests the ovary is behaving differently. It does not guarantee more eggs, and it certainly does not guarantee a baby.
Most of the underlying studies measure markers rather than live births, and large randomised trials are still lacking. This is an emerging treatment and Demeter describes it that way.
PRP and IVF for low AMH and low ovarian reserve
PRP is not a replacement for IVF. For patients with low AMH it is generally used before an IVF cycle to improve the conditions that cycle depends on.
Timing is set individually. PRP is scheduled far enough ahead of stimulation for any effect on follicle development to occur, and your IVF protocol is then chosen around your expected response rather than from a standard template. Where time is short, DuoStim double stimulation allows two egg collections within a single menstrual cycle, which can accumulate embryos faster than waiting a full cycle between attempts.
One good egg, not a bigger number
There is a temptation, when you have low AMH, to judge a cycle by how many eggs were collected. It is the wrong measure.
Demeter’s approach is built around one good egg rather than several indifferent ones. Pushing an ovary with limited reserve harder does not reliably produce more usable eggs, and it is demanding on the patient. The aim of the treatment, and of the protocols designed around it, is a better quality response so that a cycle has a genuine chance of producing the one egg that goes the distance.
That reframing changes what success looks like. Three eggs with one good embryo is a better cycle than nine eggs with none.
Who Dr Knight will and will not treat
Dr David Knight performed the first intraovarian PRP procedure in Australia in 2017 and has completed hundreds since, which means the decision about who to treat is informed by a large body of direct experience rather than by theory.
Treatment may be considered if you have low or borderline AMH, a raised FSH, diminished ovarian reserve, premature ovarian insufficiency, a poor response to previous stimulation, or you want to be sure you have exhausted the options for using your own eggs.
It is less likely to help if your difficulty conceiving is driven by something other than ovarian response, such as tubal, uterine or male factors, or if you are well into established menopause. In those cases you will be told so.
If the answer is donor eggs
Sometimes it is, and that deserves saying plainly rather than being left as an implication.
Donor eggs have better and more predictable success rates than any attempt to improve your own ovarian response. If that becomes the most realistic path for you, we will say so directly.
What we will not do is present it as your only option simply because your AMH is low. Many patients want to know they explored everything available before making that decision, and that is a legitimate thing to want.
What to do next
If you have a low AMH result and want to know whether ovarian rejuvenation is worth considering in your case, the next step is an assessment. Dr Knight will look at your markers, your history and your previous cycles and give you a direct answer, including if that answer is that this treatment is unlikely to help you.
Treatment is performed at Demeter Fertility’s Hurstville and Liverpool locations, with telehealth consultations available for interstate and international patients.
FAQs About Low AMH and PRP Therapy in Sydney
Improvements in AMH and antral follicle count after ovarian PRP have been reported across a number of studies, including a 2024 systematic review of 38 studies covering 2,256 women. Results vary between individuals, some women see no change, and an improved marker does not guarantee a pregnancy.
No diet, supplement or lifestyle change has been shown to permanently raise AMH or restore ovarian reserve. Lifestyle measures may support your general fertility and your response to treatment, but they do not change the underlying reserve.
That depends on your age, your antral follicle count, your FSH and how you responded to previous stimulation, not on the AMH figure alone. Dr David Knight assesses each case individually and will tell you if he does not expect the treatment to help.
Ovarian PRP is generally used ahead of an IVF cycle rather than instead of one, with the aim of improving the response to stimulation. Timing between the procedure and the start of stimulation is set individually.
There is no reliable number, because it depends on your starting reserve and how you respond. The more useful measure is quality rather than quantity. A cycle producing three eggs including one good embryo is a better result than a cycle producing nine with none.
Possibly. Donor eggs have better and more predictable success rates than any attempt to improve your own ovarian response. Ovarian rejuvenation is for patients who want to exhaust the options for using their own eggs first, and Dr Knight will be direct with you if donor eggs become the most realistic path.
There is no cut off at Demeter Fertility. We have no age limit and no minimum AMH for assessment. Whether treatment is likely to help is a clinical judgement made after reviewing your full picture, not a threshold applied from a chart.