Why we get such great outcomes

Demeter Fertility is about Innovation backed by Experience. While a lot of IVF clinics talk about doing “new” things or have esoteric research projects, Demeter Fertility looks for fertility treatments that can be introduced to improve your chance of having a baby.

We have been early adopters of many techniques that are only now slowly becoming mainstream fertility treatments. The obvious example is Mild Ovarian Stimulation. Our Medical Director, Dr David Knight has more than a decade of experience in using this technique, and we still see that most IVF clinics continue to use old approaches with high doses of drugs. See Dr Knight talking about MOS below.

More than a quarter of the IVF treatments performed in Australia are on women in their 40s. Demeter Fertility is proud of our Over 40s program. Dr David Knight, our Founder and Medical Director, has been using treatment approaches that improve pregnancy rates for women in the age group for the past 15 years. He has had some extraordinary IVF success stories with these approaches. In fact his personal pregnancy rate in this population group is double the average pregnancy rate reported in the mainstream literature and calculated using online algorithms*. 

The Over 40s program consists of a series of supplements, in combination with age appropriate treatment approaches and hormone regimen choices. This program is was used by Drs Jessup and Knight in their successful quest to have a child with IVF, and has been refined as further scientific information becomes available. Our fertility supplements programme is scientifically developed and based, in conjunction with the most effective forms and doses of FSH to maximise baby chances. Sometimes it’s not only what you use but also how you use it.

Getting the right egg

A short discussion about how the ovary works will give some understanding of why this is the case. Our Medical Director, Dr David Knight explains:

The ovary contains lots of eggs, about 1 to 2 million eggs at birth, around 400,000 eggs at puberty and loses about 1,000 eggs each month.

Of the thousand eggs that die every month, maybe 5-50 at any one time, will be in a state that allows them to respond to the body’s hormones. These eggs all begin to grow, and the egg that is the most competent is the only one released. “Most competent” egg means that egg that is the best able to perform all the tasks required, compared with all the others around at that time.

The eggs grow in little pouches of fluid in ovaries called follicles (or cysts). The ovary has internal workings to choose the follicle with the most competent egg to grow and mature during the natural cycle in the human species. This means - of all the eggs around at the time that might respond to the body’s hormones.

This is important, because we have already learned that women don’t end up having a baby every month they have sex in cycles where they have produced an egg. It means that there are times where even though the body has chosen the best egg available, those eggs simply aren’t good enough to make a baby. In fact, we now know that this is what happens most of the time. This is normal for humans.

Mild Ovarian Stimulation

Fertility treatment is a balance between success and patient discomfort; complications and cost, and how these might improve by simpler ovarian stimulation protocols aimed at retrieving fewer oocytes. Not only that, new data clearly tells us that giving higher doses of hormones reduces the chances of pregnancy! And this information is based on more than 650 000 IVF cycles. It also clearly shows that more eggs does not mean more babies.

Mild Ovarian Stimulation (MOS) is defined as the administration of low doses and for fewer days of FSH injections in GnRH antagonist co-treated cycles for ovarian stimulation in women undergoing IVF, aiming to limit the number of eggs collected to less than eight. Conventional protocols that are currently applied in most clinics, with a target of generating between 8 and 15 oocytes, are complex, time consuming and expensive and may give rise to considerable patient discomfort and chances for complications, especially ovarian hyperstimulation syndrome (OHSS).

MOS is more difficult and less convenient for doctors and IVF units, but is much more convenient and tolerable for patients. At the conclusion of treatment, MOS approaches result in the same number of live babies when compared with conventional stimulation approaches. There are less side effects, less eggs, less embryos and the same number of babies.


Demeter Fertility’s personalised fertility treatment programs that we deliver from our Sydney IVF clinics continues to deliver exceptional results for our clients. Contact us for more information.

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